| 三维打印珍珠粉-硫酸钙/聚己内酯复合支架及性能研究 |
| 3D Printing of Pearl-CaSO4/PCL Composite Scaffolds and Their Properties |
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| DOI：10.16253/j.cnki.37-1226/tq.2017.05.005 |
| 中文关键词: 三维打印 骨修复 支架 珍珠粉 硫酸钙 |
| 英文关键词:3D printing Bone repair Scaffolds Pearl Calcium sulfate |
| 基金项目:上海理工大学科技发展项目 (2017KJFZ010)。 |
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| 中文摘要: |
| 具有生物相容性的支架可以作为可控的细胞外环境，供细胞附着、增殖、分化以及组织生成，在组织工程中有着重要的作用。本研究运用三维打印技术制备了珍珠粉-硫酸钙/聚己内酯 (Pearl-CaSO4/PCL) 复合支架，详细研究了珍珠粉含量对复合支架的理化性能和生物学性能的影响。结果表明，复合支架具有350 mm左右的三维连通大孔，其孔隙率约60%，支架强度可达8 MPa。珍珠粉的复合能够有效调节复合支架的降解速率并稳定支架周围的体液环境。细胞实验结果表明，Pearl-CaSO4/PCL复合支架能够促进骨髓间充质干细胞的增殖与分化，且与珍珠粉的含量呈正相关。因此，Pearl-CaSO4/PCL复合支架在骨缺损修复领域具有应用前景。 |
| 英文摘要: |
| Three-dimensional porous scaffolds, acting as temporary support for cell adhesion, proliferation and differentiation, play a very important role in bone tissue engineering. In this study, pearl-CaSO4/PCL composite scaffolds were successfully fabricated by 3D printing. The structure, bioactivity, cell proliferation and alkaline phosphatase (ALP) activity of the pearl-CaSO4/PCL scaffolds were investigated. The results showed that pearl-CaSO4/PCL composite scaffolds with different pearl amounts had a regular and uniform square macroporous structure (~350 μm) and high porosity (~60%), which was beneficial for tissue growth and nutrition transportation. The compressive strength of pearl-CaSO4/PCL composite scaffolds was up to 8 MPa after curing for 3 days. Furthermore, the pearl addition tailored the degradation rates of scaffolds and stabilized pH environment. Importantly, the pearl-CaSO4/PCL scaffolds stimulated the proliferation and ALP activity of BMSCs with increasing pearl component. Therefore, 3D printed pearl-CaSO4/PCL composite scaffolds would be promising candidates for bone repair. |
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